Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which ...

Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...

Biohub and UC Berkeley show that the laser phase plate, a revolutionary device with a laser 100 million times brighter than ...

How large, fully folded proteins can pass through cell membranes without destroying them has long been one of the open ...

Scientists have developed a new imaging technique that uses a novel contrast mechanism in bioimaging to merge the strengths of two powerful microscopy methods, allowing researchers to see both the ...

With a so-called cryo plasma-FIB (Plasma Focused Ion Beam) scanning electron microscope with nanomanipulator, Goethe University in Frankfurt (Germany) is expanding its research infrastructure with a ...

Using a tiny, spherical glass lens sandwiched between two brass plates, the 17th-century Dutch microscopist Antonie van Leeuwenhoek was the first to officially describe red blood cells and sperm cells ...

Fifteen years ago, physicists worked out a method to increase image contrast by hitting the electron imaging beam with an ...

Liquid cell electron microscopy (LC-EM) has emerged as a transformative tool for observing nanoparticles in their native, fluid environment with nanometre spatial resolution and millisecond temporal ...

Stretching protein samples in all directions pulls molecules farther apart, allowing them to be visualized using only light ...