While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the current issue of Science, Nikolaus ...
Recent studies have revealed key features of circRNA biogenesis and fate, which differ from those of linear RNAs. Back-splicing is carried out by the spliceosome and is regulated by cis-complementary ...