The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers have developed a novel method for simultaneously recording action potentials (APs)—temporary changes in electrical potential when cells become excited—and calcium transients—calcium ...

New mechanism found: Researchers discovered that statins can bind to and activate ryanodine receptors in muscle cells, potentially explaining muscle pain in some patients. Why it matters: Uncovering ...

Supplements are generally not necessary for healthy individuals who can get their nutrients from diet. However, they are ...

Calcium-activated ion channels in smooth muscle cells translate intracellular calcium signals into changes in membrane potential and contractile tension. The most prominent of these channels are the ...

Until now, the details of that interaction were unclear. Using cryo-electron microscopy, a powerful imaging method that allows researchers to see structures down to individual atoms, the Columbia team ...