ascopubs.org

Pharmacokinetic–pharmacodynamic (PK-PD) modeling and simulation of serdemetan-induced QTc effects in a first-in-human study.

Background: Serdemetan is a compound that can cause replicative stress type responses in tumor cells and it has been administered to patients with solid tumors. ECG data from an ongoing first-in-human ...
FierceBiotech

Roche uses PK/PD modeling to screen compounds

One PK/PD model helps researchers predict the disposition of a drug from the body and its penetration to the target organs. The model incorporates data from animal tests on the new drug and on a ...
Business Wire

Certara Launches Version 8.1 of its Industry-leading Phoenix PK/PD Modeling and Simulation Software; Introduces Professional Certification Program

PRINCETON, N.J.--(BUSINESS WIRE)--Certara®, the global leader in model-informed drug development, regulatory science, market access and real-world evidence services, today announced the launch of ...
ascopubs.org

Pharmacokinetic–pharmacodynamic (PK-PD) modeling and simulation of serdemetan-induced QTc effects in a first-in-human study.

Bioavailability of the hedgehog pathway inhibitor GDC-0449 in a phase I pharmacokinetic (PK) study in healthy female subjects. Background: Serdemetan is a compound that can cause replicative stress ...