The molecular identity of the human mitochondrial calcium uniporter has now been elucidated using integrative genomics. The mammalian uniporter is a protein complex consisting of the inner ...

Calcium entering mitochondria potently stimulates ATP synthesis. Increases in calcium preserve energy synthesis in cardiomyopathies caused by mitochondrial dysfunction, and occur due to enhanced ...

Mitochondria are key integrators of cellular calcium (Ca2+) signaling and energy metabolism. Early studies demonstrated that isolated mitochondria could buffer huge amounts of Ca2+ via a highly ...

A team of scientists from Temple University School of Medicine and the University of Pennsylvania has moved another step closer to solving a decades-long mystery of how the all-important flow of ...

While calcium's importance for our bones and teeth is well known, its role in neurons -- in particular, its effects on processes such as learning and memory -- has been less well defined. A new study ...

PHILADELPHIA — Most healthy cells rely on a complicated process to produce the fuel ATP. Knowing how ATP is produced by the cell's energy storehouse – the mitochondria -- is important for ...

Knowing how ATP is produced by the cell’s energy storehouse – the mitochondria -- is important for understanding a cell’s normal state, as well as what happens when things go wrong, for example in ...