When microglia wind up with a belly full of lipid droplets, it’s a sign that the cells are rallying, perhaps in vain, to a neurodegenerative threat. But according to a study published July 10 in Cell ...

In trying to treat neuroinflammation, scientists need better ways to visualize microglia in the brains of living people. Current microglial PET tracers target the mitochondrial transporter TSPO, but ...

New research has shown that Sonic Hedgehog (SHH)–Gli1 signaling in microglia amplifies inflammatory responses through the IKKβ/NF-κB pathway, contributing to dopaminergic neuron loss in Parkinson’s ...

Alzheimer's disease (AD) is a highly debilitating neurodegenerative disease characterized by the progressive loss of memory and decline of mental functions. Earlier research has uncovered some of the ...